23.04.21

The Department of Animal Developmental Biology  of the Faculty of Biological Sciences, University of Wrocław, Poland 

is looking for a

PhD candidate in animal developmental biology with a focus on a new animal model of  human McArdle disease in zebrafish (Danio rerio) 

Project description

Mutations in muscle glycogen phosphorylase (PYGM) gene lead to autosomal recessive  human McArdle disease, characterized by onset of exercise intolerance and muscle cramps in  childhood and adolescence. 

The goal of the project is to create a new animal model of human McArdle disease utilizing  zebrafish using a CRISPR-Cas9 method. We plan in-depth characteristic (morphological, biochemical, behavioral and molecular) of obtained zebrafish with pygm knock-out. Additionally, 

we will analyze selected substances influence on the physical performance of the pygm-/- zebrafish.  An effective animal model for human McArdle disease in zebrafish is important for  effective therapeutics searching. 

Key responsibilities

The primary task of the PhD candidate will be taking part in morphological and behavioral  assessment of the zebrafish model and potential drug testing. His/her responsibility will also include  the extensive care of animals welfare. 

The PhD project will be a part of a wide research plane described above. The PhD candidate  will therefore be a research group member and have a supervisor support during performing the experiments. 

Selection criteria

• A Master’s degree in Biology, Genetics, or a related field;

• A strong interest in the research with the use of molecular biology techniques;

• Willingness and proven ability to perform laboratory research;

• Laboratory skills;

• Ability to work in team;

• Willingness to travel and undertake part of the research training and/or experiments abroad

(once restrictions have lifted);

• Fluency in spoken Polish and English excellent writing skills in Polish and English.

Information

For information about the positions and the project please contact Prof. dr hab. Małgorzata  Daczewska, e-mail: malgorzata.daczewska@uwr.edu.pl with CC to marta,migocka-patrzalek@uwr.edu.pl 

Applications

Please submit online your application (CV and recommendation letter/s) via e-mail